Could Low-Dose Naltrexone help manage arthritis?

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Could Low-Dose Naltrexone help manage arthritis?

What is arthritis? What are the symptoms of arthritis?

Rheumatoid Arthritis (RA) is an inflammatory progressive disease that can lead to the destruction of skeletal joints and could cause disability in the absence of appropriate treatment. Under this condition, the immune system of the body attacks the lining membrane of the joint capsule. In patients affected by RA, this membrane becomes inflamed and swollen, eventually damaging the cartilage and bone within the joint. In brief, this article explains the possible applications of low-dose Naltrexone(LDN) for arthritis.

How do doctors usually treat arthritis?

Various treatment options for Arthritis exist such as rest, occupational therapy, physiotherapy, exercise, drugs, and surgery in certain cases to correct joint damage. Although such treatments can help relieve pain and stiffness, the disease may still continue to progress.

What is low-dose naltrexone (LDN)?

It has been demonstrated that Low-dose Naltrexone (LDN) reduces the severity of symptoms in conditions such as Fibromyalgia, Multiple Sclerosis, Crohn’s disease, and complex regional pain syndrome. In 1984, the FDA approved the use of full-dose naltrexone for treating opioid addiction, but in recent years, Low Dose Naltrexone has been used as an off-label therapy for several chronic diseases. Various clinical studies have shown results that indicate the beneficial effects of LDN for autoimmune disease.

How could LDN help arthritis?

There have been several clinical studies using low-dose Naltrexone for the treatment of arthritis. All reported less pain after treatment with LDN. Dr. Guttorm Raknes from the University Hospital of North Norway says that patients with Rheumatoid arthritis who started using LDN continuously were able to reduce the use of disease-modifying drugs and painkillers. In those studies, inflammatory markers were also reduced during LDN use.

Dr. Jarred Younger, an Associate Professor at the University of Alabama at Birmingham believes low-dose Naltrexone is a good treatment option because of its low cost and minimal side effects. Additionally, the most common side effects reported were vivid dreams and insomnia.

While the knowledgeable pharmacists at The Compounding Center do our best to share accurate scientific information, we also understand that first-hand accounts from actual patients are also valuable.

Notably, on the LDN Research Trust website, you will find accounts of patients’ experiences with LDN for managing arthritis. We encourage you to talk to your doctor about whether LDN might be appropriate for you to try.

Where Can I Try LDN?

If you live in NY, PA, MD, DC, VA, WV, NC, and GA, our trained pharmacy staff will compound your specific LDN dose with a prescription from your doctor.

The Compounding Center in Leesburg prepares LDN as immediate-release pills with no fillers or binders to interfere with the drug’s absorption. At the same time, we take your allergies and dietary concerns into consideration. We make sure our compounded LDN capsules and tablets are free of common allergens like gluten, lactose, and dyes.

We’ll even ship it to you if you can’t get to the store!

Give us a call to get a quote.
The Compounding Center

For more information, visit:



LDN Research Trust

LDN Science

PubMed Study

PubMed Study